PubMed

Selected Publications

Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs. Bae H, Kim BR, Jung S, Le J, van der Heide D, Yu W, Park SH, Hilkin BM, Gansemer ND, Powers LS, Kang T, Meyerholz DK, Schuster VL, Jang C, Welsh MJ.J Clin Invest. 2024 May 14;134(13):e174500. doi: 10.1172/JCI174500.PMID: 38743489

Mitochondrial uncoupling proteins protect human airway epithelial ciliated cells from oxidative damage. Jain A, Kim BR, Yu W, Moninger TO, Karp PH, Wagner BA, Welsh MJ. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2318771121. doi: 10.1073/pnas.2318771121. Epub 2024 Feb 28.PMID: 38416686

A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1. Riley MJ, Mitchell CC, Ernst SE, Taylor EB, Welsh MJ.Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2318956121. doi: 10.1073/pnas.2318956121. Epub 2024 Feb 20.PMID: 38377207

Inflammation as a Regulator of the Airway Surface Liquid pH in Cystic Fibrosis. Rehman T, Welsh MJ. Cells. 2023 Apr 7;12(8):1104. doi: 10.3390/cells12081104.PMID: 37190013

A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis. Thurman AL, Li X, Villacreses R, Yu W, Gong H, Mather SE, Romano-Ibarra GS, Meyerholz DK, Stoltz DA, Welsh MJ, Thornell IM, Zabner J, Pezzulo AA. Am J Respir Cell Mol Biol. 2022 Jun;66(6):612-622. doi: 10.1165/rcmb.2021-0499OC.PMID: 35235762

Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs. Pino-Argumedo MI, Fischer AJ, Hilkin BM, Gansemer ND, Allen PD, Hoffman EA, Stoltz DA, Welsh MJ, Abou Alaiwa MH. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2121731119. doi: 10.1073/pnas.2121731119. Epub 2022 Mar 24.PMID: 35324331

WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia. Rehman T, Karp PH, Thurman AL, Mather SE, Jain A, Cooney AL, Sinn PL, Pezzulo AA, Duffey ME, Welsh MJ.Am J Respir Cell Mol Biol. 2022 Oct;67(4):491-502. doi: 10.1165/rcmb.2022-0172OC.PMID: 35849656

A pilot to assess target engagement of terazosin in parkinson’s disease. Schultz JL, Brinker AN, Xu J, Ernst SE, Tayyari F, Rauckhorst AJ, Liu L, Uc EY, Taylor EB, Simmering JE, Magnotta VA, Welsh MJ, Narayanan NS. Parkinsonism Relat Disord. 2022 Jan;94:79-83. doi: 10.1016/j.parkreldis.2021.11.022. Epub 2021 Nov 27. PMID: 34894470; PMCID: PMC8862665.

Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs. Yu W, Moninger TO, Thurman AL, Xie Y, Jain A, Zarei K, Powers LS, Pezzulo AA, Stoltz DA, Welsh MJ. Proc Natl Acad Sci U S A. 2022 Jan 25;119(4):e2119759119. doi: 10.1073/pnas.2119759119. PMID: 35046051; PMCID: PMC8794846.

 Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction. Yu W, Moninger TO, Rector MV, Stoltz DA, Welsh MJ. Dev Cell. 2022 Sep 26;57(18):2221-2236.e5. doi: 10.1016/j.devcel.2022.08.010. Epub 2022 Sep 14. PubMed PMID: 36108628; PubMed Central PMCID: PMC9762774.

Use of Glycolysis-Enhancing Drugs and Risk of Parkinson's Disease. Simmering JE, Welsh MJ, Schultz J, Narayanan NS. Mov Disord. 2022 Nov;37(11):2210-2216. doi: 10.1002/mds.29184. Epub 2022 Aug 22. PubMed PMID: 36054705; PubMed Central PMCID: PMC9669185.